Topic outline
Cancer Biology and Molecular Biology
This content is going to discuss a lecture titled “Cancer Biology and Molecular Biology” for the Cancer Genome-based Medicine Course as part of the presentation series in the ATLAS Training Program.
0:27:38
Basic terms used in genomic medicine
A leading scientist explains basic terms used in genomic medicine, from those related to introductory molecular biology to the genetic diagnosis technology.
0:27:09
Sample handling
1. Sample Handling Process in Cancer Genomic Medicine
2. Tumor Sample Evaluation Procedure
3. Examples of Tumor Evaluation
4. Tumor Sample Evaluation (Tumor Cell Content)0:20:50
Central Review of Pathology Specimens
Information on the topics listed on this slide will be presented in the lecture.
1.Outline of MASTERKEY-Asia
2.Efforts of the Department of Diagnostic Pathology
3.Preparation of pathology specimens and quality check of submitted samples
4.Pathology review0:25:51
Next-generation sequencing principles and analysis files
Information on the topics listed on this slide will be presented in the lecture.
・Understand the flow of gene panel testing.
・Understand the principles of next-generation sequencing (NGS)
・Learn about data formats for analyses.0:19:13
Procedures and Interpretation of Next Generation Sequencing Results
1. Characteristics of gene panel tests and interpretation of the results
2. Pathogenic significance of detected mutations
3. Mutations and associated therapeutic agents
4. Candidate drugs and their evidence levels0:18:06
Medical genetics and Hereditary tumors
1. Hereditary tumors
2. Actual response to germline findings in oncogene panel testing
・Points to note when discussing genetic test results with the patient
・Evaluation by an expert panel
・Points to note when disclosing the germline findings and actual response in outpatient genetic counseling0:32:40
Communication with Patients when Providing Genomic Testing Results
Information on the topics listed on this slide will be presented in the lecture.
1 Patients' understanding and expectations of comprehensive genomic profiling of cancers
2 Communication when providing the results of comprehensive genomic profiling of cancers
・Know the basic elements of communication
・Communication tips
・Points to note for comprehensive genomic profiling of cancers0:46:00
Administrative perspectives and staffing to conduct genomic medicine
This content will discuss these three main topics,
1.To understand the facilities and personnel required to implement genomic medicine.
2.To understand the structure of medical care systems involving genomic medicine.
3.To understand treatment options based on genomic testing.0:30:25
Second opinion and Management
Information on the topics listed on this slide will be presented in the lecture.
What is second opinion?
・What is genomic report?
・Where to find the clinical trial for your genomic findings?
・Pitfalls in genomic test, clinical trials, and Second Opinion.0:34:43