SCT: Data Monitoring Committees
This course is a two-part e-learning module about interim analyses and Data Monitoring Committees (DMCs) created by the Society for Clinical Trials (SCT). The instructors are world-renowned statisticians in this field.
The SCT also publishes numerous other educational materials on DMC. Those interested can explore them via the following link: https://www.sctweb.org/dmctraining/.
This course is a two-part e-learning module about interim analyses and Data Monitoring Committees (DMCs) created by the Society for Clinical Trials (SCT). The instructors are world-renowned statisticians in this field.
The SCT also publishes numerous other educational materials on DMC. Those interested can explore them via the following link: https://www.sctweb.org/dmctraining/.
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1. DMC Structure and Function by Dr. David DeMets and Dr. James Meaton
1. DMC Structure and Function by Dr. David DeMets and Dr. James Meaton
In this lecture, the statisticians talk about the history and functions of DMC.0:00:00- [Introduction]0:07:30- [Part I] Data Monitoring Committee Structure & Function0:11:24- [I-A] Brief History of Data Monitoring Committees0:26:25- [I-B] DMCs for Industry-sponsored Trials0:35:57- [I-C] DMC Review Process0:43:45- [I-D] DMC Recommendations0:51:05- [I-E] DMC Membership1:00:05- [I-F] Special Issues1:08:42- [I-G] DMC Meeting Reports1:32:00- [I-H] DMC Summary
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2. DMC Case Studies by Dr. James Meaton and Dr. David DeMets
2. DMC Case Studies by Dr. James Meaton and Dr. David DeMets
In this lecture, the operational aspects of DMC are explained through case studies, and the course is then summarized.0:00:00- [Part II] Data Monitoring Committee Examples0:04:45- Trial Examples0:48:13- DMC Reaffirming Recommendations1:05:36- Trial Examples: External Data1:28:13- Need for Replication1:29:29- Sharing Data1:37:00- Data Lags and Subgroup Findings1:38:41- Importance of Statistical Analysis Center1:39:24- [Part III] Statistical Methods Overview1:39:53- [Summary and Conclusion]